Andy Murray is due on court at 1600 BST on Wednesday after his scheduled match on Tuesday was cancelled due to heavy rain in New York.
The British number one was due to take on American wildcard Donald Young in the fourth round yesterday but the bad weather meant all play on day nine was postponed.
The mens final has been played on the third Monday for the past three years and it appears heavy rain could force organisers to schedule a fourth.
"The forecast indicates worsening conditions with no projected breaks in the rain through the day and into the night," a statement from the US Open read.
Wednesday will offer a packed order of play with Murray's match being switched to the Grandstand court. Rafa Nadal will take on Gilles Muller in the Arthur Ashe Stadium while Andy Roddick faces fifth seed David Ferrer on Loius Armstrong. All three matches will begin at 1600 BST.
However, more rain is expected in New York on Wednesday with bad weather forecast for the rest of the week.
"We're playing it by ear, half-hour by half-hour, trying to get them on," said tournament referee Brian Earley before play was called off.
"We need the bottom half of the men's draw played as quickly as we can. The other half of the men's draw and the whole of the women's draw are into the quarter-finals already.
"I'm confident of finishing the men's tournament on Sunday and the women's on Saturday. There are some challenges down the road but we'll take it one day at a time."
Connect with Sportsvibe by joining our social media network. Join the debate to get your voice heard and stay informed with up-to-the-minute news, videos, competitions and articles from the world of sport.